Everyone is asking, "Does Cold Laser Therapy Regenerate Cartilage?"
The answer is a clear YES, according to numerous clinical studies including the clinical studies revealed below. Plus, many of our customers are raving about the rejuvenation that they are experiencing in their knees, backs, spine, facial rejuvenation and most joints of the body.
The following is a summary of some of the clinical studies that were conducted using cold laser to treat cartilage regeneration. These studies are presented here to demonstrate the wide uses of a cold lasers in the treatment of different medical conditions.
Histological and clinical responses of articular cartilage to low-level laser therapy: Experimental study
I. Ruiz Calatrava1 , J. M. Santisteban Valenzuela1, R. J. GÃ³mez-Villamandos1, J. I. Redondo1, J. C. GÃ³mez-Villamandos1 and I. Avila Jurado1 (1) Department of Veterinary Clinical Pathology-Surgery, Faculty of Veterinary Medicine, University of Cordoba, Avda. Medina Azahara, 9, 14005 CÃ³rdoba, Spain
Received: 30 July 1996 Revised: 18 September 1996 Accepted: 20 November 1996
This study was carried out to evaluate the effects of low-level laser irradiation on experimental lesions of articular cartilage. A standard lesion was practiced on the femoral trochlea of both hind-limbs of 20 clinically normal Californian rabbits. These animals were divided into two groups of 10 individuals each, depending on the laser equipment used for treatment.
One group was treated with He-Ne laser (8 J cm-2, 632.8 nm wavelength) and the other with infra-red (IR) laser (8 J cm-2, 904 nm wavelength). In both groups, five points of irradiation to the right limb alone were irradiated per session for a total of 13 sessions, applied with an interval of 24 h between sessions. These points were the following: left and right femoral epicondyles, left and right tibial condyles and the centre of articulation. The distance between these points was approximately 1 cm.
The untreated left limb was left as a control. During treatment, extension angle and periarticular thickness were considered. At the end of the treatment, samples were collected for histopathologi-cal study and stained with: Haematoxylin-Eosin, PAS and Done. The results show a statistically higher anti-inflammatory capacity of the IR laser (p < 0.0001). The functional recovery was statistically similar for both treatments (p < 0.176). Histological study showed, at the end of the treatment, hyaline cartilage in the IR group, fibrocartilage in the He-Ne group and granulation tissue in the control limbs. Clinical and histological results indicated that this laser treatment had a clear anti-inflammatory effect that provided a fast recuperation and regeneration of the articular cartilage.
"LLLT triggers biostimulative-regenerative processes inside the cell and subsequently causes revitalisation of the tissue as well. Second effect of LLLT refers to the vasodilatation and neovascularisation of local blood and lymph vessels, thus causing a better removal of waste products and, on the other hand, improved oxygenation and nutrition of damaged tissue. Analgesic and anti-inflammatory effects of LLLT are also significant when irradiating certain dermatological changes."
1 Zlatko Simunovic, M.D., F.M.H.,
2 Tatjana Trobonjaca, M.D.
3 Pain Clinic-Laser Center, Locarno, Switzerland
4 Laser Center, Opatija, Croatia
Studies on Cold Laser Therapy and its Effects on Cartilage Regeneration
Over the years, several studies have been performed to determine the effects of cold laser therapy on cartilage regeneration.
One study took a cartilage sample from the right knee of a 19 year old patient. Chondrocytes (cartilage cells) were isolated and suspended for cultivation, and cultures were incubated for 10 days. The cultures were then separated into 4 groups. The first three groups of cultures received cold laser treatments for 10 minutes for five consecutive days. Each culture had different laser parameters assigned to it. Group 4 was the control group and did not receive any treatments.
The Groups that were treated with laser showed great results in terms of cell viability and higher levels of Calcium and alkaline phosphate as compared to the untreated group. This study concluded that laser therapy improved chondrocyte activity without causing any damage to the cell.
And in a separate study published in Biotechnology cold laser therapy was performed on holes drilled in mice’s ears to determine if cartilage would grow back. Mice were chosen as the subject because the chondrocytes (cartilage cells) in mice’s ears are similar to those in human cartilage. In the study, holes were drilled in both ears. The left ear was treated with cold laser therapy while the right ear was left untreated. The results indicated that after two days only the treated ear showed clear evidence of perichondrium (precursor to cartilage) while the untreated ear showed NONE. After four days the treated ear had significant ingrowth of perichondrium into the hole versus the control group were there was only an active perichondrium zone.
Macroscopical and histological examinations revealed that cold laser therapy had a direct effect on cartilage regeneration.
Many patients who were diagnosed with ‘bone on bone’ knee pain, and osteoarthritis of the knee have turned to Cold Laser Therapy with regular in-home treatment, which has helped them experience knee pain relief so that they could avoid knee surgery.
1.Biostimulation Of Human Chondrocytes With Ga-Al-As Diode Laser: ‘In Vitro’ Research. Morrone G, Guzzardella G A, Tigani D Et Al. Lasers Surg Med. 1997;21(5):480-4.
2. THE INFLUENCE OF LOW LEVEL INFRA RED LASER THERAPY ON THE REGENERATION OF CARTILAGE TISSUE P.Lievens , Ph.Van Der Veen. Biotechnology. 2000; 28(2):193-201.
Cold Laser Research on Arthritis and Cartilage Issues
Here are just a handful of additional studies that show how effective cold laser treatment is for relief from knee pain and Arthritis:
There are over 35 years of worldwide clinical success, 2,500 published papers and 120 randomized, controlled trials for cold lasers. It is the only therapeutic modality with a cumulative effect on cells and tissues. Both NASA and the US Defense Advanced Research Projects Agency have engaged in cold laser therapy research over the last decade, with noteworthy success.
The Effect of Low Power Laser Therapy (Cold Laser) on Osteoarthritis of the Knee
Basirnia A., Sadeghipoor G., Esmaeeli Djavid G. et al. Radiol Med (Torino).1998 April; 95 (4):303-9.
…We achieved significant improvement inpain relief and quality of life in 70% of patients.
Positive Outcomes for Infrared diode laser in low reactive-level laser therapy (cold laser) for knee osteoarthritis.
M.A. Trelles, J.Rigau, P. Sala, G. Calderhead, T. Ohshiro. Laser Therapy, (1991): 3(4): 149-153. 82% reported significant removal of pain and recovery of joint mobility. Cold Laser Therapy is concluded to be a safe effective and noninvasive alternative to conventional surgical and medical treatment modalities for DJD patients.
The Influence Of Low Level Infra Red Laser Therapy On The Regeneration Of Cartilage Tissue.
P. Lievens, Ph. Van der Veen.Abstract from Laser Florence 2002. Laser in Medical Science. 2002:17(4).
This study concerns the influence of Laser treatment on the regeneration process of cartilage tissue. There is no need saying that the regeneration of cartilage tissue is a very big problem in rheumatic diseases for example. The lack of blood supply is one of the most important factors involved. Lots of previous publications give us proof of the regeneration capacities of Laser Therapy. In this study we have chosen to experiment on cartilage tissue of the ear of mice….Microscopic as well as histological evaluations were performed on the cartilage regeneration of both ears… After the second day, only in the irradiated group there is a clear activation of the perichondrium (the connective tissue surrounding cartilage).
Beneficial Effects of Laser Therapy in the early stages of Rheumatoid Arthritis onset
Ailioaie C, Lupusoru-Ailioaie LM. Laser Therapy (1991) 11(2); 9-87
The purpose of this study was to determine the effects of laser therapy in pain reduction and /or recovery of patients at the onset of Rheumatoid Arthritis, comparatively with the traditional non-steroidal anti-inflammatory drugs (NSAIDS). Group 1 received laser therapy, Group 2 received placebo laser therapy, Group 3 was treated with only NSAIDS….The overall efficacy rate in these studies was 86% in the first group (who just had laser), 50% in the placebo group, and 40% in the NSAIDS treated group. After 4 months of treatment,our investigations showed the laser therapy group promoted the restoration of function, relieved pain and limited the complications of Rheumatoid Arthritis.
Improvement of Pain and disability in elderly patients with degenerative osteoarthritis of the knee treated with low power light therapy (cold laser therapy)
Stelian J, Gil I , Beni-Habot, Rosenthal M, Abramovici I, Kutok N, Khalil A. Journal American Geriatric Society. (January 1992) 40 (1); 23-26.
Low power light therapy (Cold laser therapy) is effective in relieving pain and disability in degenerative osteoarthritis of the knee.
Boggs, Will MD. BMC Musculoskeletal Disorders. (June 22, 2007).
People with knee pain caused by osteoarthritis may find relief with… electrical nerve stimulation, (and) low-level laser therapy (cold lasers), research shows. …Electrical stimulation and low-level laser therapy have fewer and less severe side-effects than NSAIDS, and unlike oral drugs they seem to… maintain the positive effect for some weeks after treatment has stopped…
Dr. Bjordal, MD said, “In our opinion, there is currently more short-term potential in refining these safe treatment methods for osteoarthritis than there are for drugs.”
Laser Therapy More Effective than Medication?
…From the findings of a recent Norwegian Health Technology Assessment Report, laser therapy was given the potential of becoming at least twice as effective as NSAIDS(non-steroidal anti-inflammatory drugs), if applied with optimal dose and energy… Although the number of laser trials is still smaller than for NSAIDS, the unequivocal scientific findings so far, has earned cold laser therapy a top spot in levels of evidence and treatment recommendations for knee osteoarthritis issued by the Norwegian Drug Agency.
Non-Drug Alternative for the Management of Chronic Pain
Chow RT, David MA, Armati PJ. 830nm laser irradiation induces varicosity formation, reduces mitochondrial membrane potential and blocks fast axonal flow in small and medium diameter rat dorsal root ganglion neurons: implications for the analgesic effects of 830nm laser: J Peripher Nerv Syst. 2007 Mar; 12(1):28-39. Most dramatically and recently, Australian researchers have identified a direct effect on the flow of cellular materials down the long axon that makes up the “wiring” of nerve cells. Researchers have discovered that laser-induced neural blockade is a consequence of such changes and provides a mechanism for…laser induced pain relief. The application of low level laser therapy for chronic pain may provide a non-drug alternative for the management of chronic pain.
Breakthrough in the Relief of Chronic Pain Without Drugs!
Goepp, Julius MD. Life Extension. October 2008: 63-70.
Dr. Norquist discusses his clinical outcomes for patients that received low-level laser treatments. “Out of 300 patients more than 90% have reported total pain relief. And more than half the others have experienced at least partial relief of their pain after 10 full treatments. Only about 2-3% of patients have truly had no beneficial effects.”
Cold Laser Research for Knee Pain
These are overwhelmingly positive results from various Cold Laser Therapy Studies on the Treatment of Knee Pain. Knee pain doctors continue to use Cold Laser Therapy to Relieve Knee Pain with great success. Many individuals report getting their own Scalar Wave Laser and using it at home to accomplish similar or better results due to the ease and convenience of getting more cold laser therapy treatments more often and for a longer time period. Thus producing superior results than time limited studies.
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